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However, a general method for measuring various aspects of selectivity (including agonist, modulator, receptor and signaling pathway selectivity) and the resulting bias based on ligand concentrations and receptor levels as well as all parameters of receptor agonism and allosterism has been lacking to date

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Various mechanisms have been implicated in the virus-induced production of pathogenic antibodies, including epitope spreading, molecular mimicry, bystander activation, and original antigenic sin [41,42,43]

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